In-Orbit Performance of the GRACE Accelerometers and Microwave Ranging Instrument

The Gravity Recovery and Climate Experiment (GRACE) satellite mission has provided global long-term observations of mass transport in the Earth system with applications in numerous geophysical fields. In this paper, we targeted the in-orbit performance of the GRACE key instruments, the ACCelerometers (ACC) and the MicroWave ranging Instrument (MWI). For the ACC data, we followed a transplant approach analyzing the residual accelerations from transplanted accelerations of one of the two satellites to the other. For the MWI data, we analyzed the post-fit residuals of the monthly GFZ GRACE RL06 solutions with a focus on stationarity. Based on the analyses for the two test years 2007 and 2014, we derived stochastic models for the two instruments and a combined ACC+MWI stochastic model. While all three ACC axes showed worse performance than their preflight specifications, in 2007, a better ACC performance than in 2014 was observed by a factor of 3.6 due to switched-off satellite thermal control. The GRACE MWI noise showed white noise behavior for frequencies above 10 mHz around the level of (Formula presented.). In the combined ACC+MWI noise model, the ACC part dominated the frequencies below 10 mHz, while the MWI part dominated above 10 mHz. We applied the combined ACC+MWI stochastic models for 2007 and 2014 to the monthly GFZ GRACE RL06 processing. This improved the formal errors and resulted in a comparable noise level of the estimated gravity field parameters. Furthermore, the need for co-estimating empirical parameters was reduced

New ultrahigh-resolution picture of Earth's gravity field

We provide an unprecedented ultrahigh resolution picture of Earth’s gravity over all continents and numerous islands within ±60° latitude. This is achieved through augmentation of new satellite and terrestrial gravity with topography data and use of massive parallel computation techniques, delivering local detail at ~200 m spatial resolution. As such, our work is the first-of-its-kind to model gravity at unprecedented fine scales yet with near-global coverage. The new picture of Earth’s gravity encompasses a suite of gridded estimates of gravity accelerations, radial and horizontal field components, and quasi-geoid heights at over 3 billion points covering 80% of Earth’s land masses. We identify new candidate locations of extreme gravity signals, suggesting that the Committee on Data for Science and Technology standard for peak-to-peak variations in free-fall gravity is too low by about 40%. The new models are beneficial for a wide range of scientific and engineering applications and freely available to the public

Joint inversion estimate of regional glacial isostatic adjustment in Antarctica considering a lateral varying Earth structure (ESA STSE Project REGINA)

A major uncertainty in determining the mass balance of the Antarctic ice sheet from measurements of satellite gravimetry, and to a lesser extent satellite altimetry, is the poorly known correction for the ongoing deformation of the solid Earth caused by glacial isostatic adjustment (GIA). Although much progress has been made in consistently modelling the ice-sheet evolution throughout the last glacial cycle, as well as the induced bedrock deformation caused by these load changes, forward models of GIA remain ambiguous due to the lack of observational constraints on the ice sheet's past extent and thickness and mantle rheology beneath the continent. As an alternative to forward modelling GIA, we estimate GIA from multiple space-geodetic observations: GRACE, Envisat/ICESat and GPS. Making use of the different sensitivities of the respective satellite observations to current and past surface mass (ice mass) change and solid Earth processes, we estimate GIA based on viscoelastic response functions to disc load forcing. We calculate and distribute the viscoelastic response functions according to estimates of the variability of lithosphere thickness and mantle viscosity in Antarctica. We compare our GIA estimate with published GIA corrections and evaluate its impact in determining the ice mass balance in Antarctica from GRACE and satellite altimetry. Particular focus is applied to the Amundsen Sea Sector in West Antarctica, where uplift rates of several cm/yr have been measured by GPS. We show that most of this uplift is caused by the rapid viscoelastic response to recent ice-load changes, enabled by the presence of a low-viscosity upper mantle in West Antarctica. This paper presents the second and final contribution summarizing the work carried out within a European Space Agency funded study, REGINA, (www.regina-science.eu)

Evaluation of the third- and fourth-generation GOCE Earth gravity field models with Australian terrestrial gravity data in spherical harmonics

In March 2013 the fourth generation of ESA’s (European Space Agency) global gravity field models, DIR4 (Bruinsma et al, 2010b) and TIM4 (Pail et al, 2010), generated from the GOCE (Gravity field and steady-state Ocean Circulation Explorer) gravity observation satellite were released. We evaluate the models using an independent ground truth data set of gravity anomalies over Australia. Combined with GRACE (Gravity Recovery and Climate Experiment) satellite gravity, a new gravity model is obtained that is used to perform comparisons with GOCE models in spherical harmonics. Over Australia, the new gravity model proves to have significantly higher accuracy in the degrees below 120 as compared to EGM2008 and seems to be at least comparable to the accuracy of this model between degree 150 and degree 260. Comparisons in terms of residual quasi-geoid heights, gravity disturbances, and radial gravity gradients evaluated on the ellipsoid and at approximate GOCE mean satellite altitude (h=250 km) show both fourth generation models to improve significantly w.r.t. their predecessors.Relatively, we find a root-mean-square improvement of 39 % for the DIR4 and 23 % for TIM4 over the respective third release models at a spatial scale of 100 km (degree 200). In terms of absolute errors TIM4 is found to perform slightly better in the bands from degree 120 up to degree 160 and DIR4 is found to perform slightly better than TIM4 from degree 170 up to degree 250. Our analyses cannot confirm the DIR4 formal error of 1 cm geoid height (0.35 mGal in terms of gravity) at degree 200. The formal errors of TIM4, with 3.2 cm geoid height (0.9 mGal in terms of gravity) at degree 200, seem to be realistic. Due to combination with GRACE and SLR data, the DIR models, at satellite altitude, clearly show lower RMS values compared to TIM models in the long wavelength part of the spectrum (below degree and order 120). Our study shows different spectral sensitivity of different functionals at ground level and at GOCE satellite altitude and establishes the link among these findings and the Meissl scheme (Rummel and van Gelderen in Manuscripta Geodaetica 20:379–385, 1995)

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Drug sensitivity and resistance testing on diagnostic leukemia samples should provide important functional information to guide actionable target and biomarker discovery. We provide proof of concept data by profiling 60 drugs on 68 acute lymphoblastic leukemia (ALL) samples mostly from resistant disease in cocultures of bone marrow stromal cells. Patient-derived xenografts retained the original pattern of mutations found in the matched patient material. Stromal coculture did not prevent leukemia cell cycle activity, but a specific sensitivity profile to cell cycle-related drugs identified samples with higher cell proliferation both in vitro and in vivo as leukemia xenografts. In patients with refractory relapses, individual patterns of marked drug resistance and exceptional responses to new agents of immediate clinical relevance were detected. The BCL2inhibitor venetoclax was highly active below 10 nM in B-cell precursor ALL (BCP-ALL) subsets, including MLL-AF4 and TCF3-HLF ALL, and in some T-cell ALLs (T-ALLs), predicting in vivo activity as a single agent and in combination with dexamethasone and vincristine. Unexpected sensitivity to dasatinib with half maximal inhibitory concentration values below 20 nM was detected in 2 independent T-ALL cohorts, which correlated with similar cytotoxic activity of the SRC inhibitor KX2-391 and inhibition of SRC phosphorylation. A patient with refractory T-ALL was treated with dasatinib on the basis of drug profiling information and achieved a 5-month remission. Thus, drug profiling captures disease-relevant features and unexpected sensitivity to relevant drugs, which warrants further exploration of this functional assay in the context of clinical trials to develop drug repurposing strategies for patients with urgent medical needs.Peer reviewe

Next-Generation Gravity Missions: Sino-European Numerical Simulation Comparison Exercise

Temporal gravity retrieval simulation results of a future Bender-type double pair mission concept, performed by five processing centers of a Sino-European study team, have been inter-compared and assessed. They were computed in a synthetic closed-loop simulation world by five independent software systems applying different gravity retrieval methods, but were based on jointly defined mission scenarios. The inter-comparison showed that the results achieved a quite similar performance. Exemplarily, the root mean square (RMS) deviations of global equivalent water height fields from their true reference, resolved up to degree and order 30 of a 9-day solution, vary in the order of 10% of the target signal. Also, co-estimated independent daily gravity fields up to degree and order 15, which have been co-estimated by all processing centers, do not show large differences among each other. This positive result is an important pre-requisite and basis for future joint activities towards the realization of next-generation gravity missions

Simulated gravity field solutions in icgem format

has to be submitted by autho